Notices to the Market and Material Facts

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10/01/2021	Material Fact - Change of Chief Executive Officer	- -
09/27/2021	Material Fact - MAM Asset Management Gestora de Recursos LTDA. (MAM)	- -
09/13/2021	Notice to the Market - Atypical trades of securities	- -
08/31/2021	Material Fact - OPA Withdrawal (Rede D´Or)	- -
08/23/2021	Material Fact - 1st Amendment to the Shareholders´ Agreement	- -
08/20/2021	Material Fact - Shareholders’ Agreement	- -
08/19/2021	Material Fact - Notifications received	- -
08/19/2021	Notice to the Market - Atypical trades of securities	- -
08/18/2021	Notice to the Market - Acquisition of Relevant Equity Interest	- -
08/18/2021	Notice to the Market - Stock Purchase	- -
08/18/2021	Notice to the Market - Stock Purchase	- -
08/17/2021	Notice to the Market - Stock Purchase	- -
08/16/2021	Material Fact - Unsolicited offer notification	- -
08/12/2021	Material Fact - Shareholders´ Agreement	- -
06/10/2021	Material Fact - Change of Chief Executive Officer	- -
05/28/2021	Notice to the Market - Clarifications on B3 Inquiries*	- -
05/27/2021	Material Fact - Share Buyback Program*	- -
05/13/2021	Material Fact - Clinical Analysis Operation	- -
05/10/2021	Notice to the Market - Alteration in the Board of Directors	- -
05/10/2021	Notice to the Market - Installation of the Company´s Fiscal Council	- -
04/29/2021	Notice to Shareholders - Receipt Disclosure of the Synthetic Voting Map	- -
01/14/2021	Date scheduled for the Annual Shareholders’ Meeting	- -
04/22/2021	Notice to Shareholders - Receipt Disclosure of the Synthetic Voting Map	- -
04/16/2021	Notice to the Market - Perspective Lift
04/06/2021	Notice to the Market - Change of members in the Board	- -
03/23/2021	Material Fact - Clarification on Projections	- -
03/15/2021	Notice to the Market - New Chief Financial Officer	- -
03/03/2021	Notice to the Market - New Investor Relations Director	- -
01/12/2021	Notice to the Market - New Medical Officer	- -

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