Notices to the Market and Material Facts

06/10/2021	Material Fact - Change of Chief Executive Officer	- -
05/28/2021	Notice to the Market - Clarifications on B3 Inquiries*	- -
05/27/2021	Material Fact - Share Buyback Program*	- -
05/13/2021	Material Fact - Clinical Analysis Operation	- -
05/10/2021	Notice to the Market - Alteration in the Board of Directors	- -
05/10/2021	Notice to the Market - Installation of the Company´s Fiscal Council	- -
04/29/2021	Notice to Shareholders - Receipt Disclosure of the Synthetic Voting Map	- -
01/14/2021	Date scheduled for the Annual Shareholders’ Meeting	- -
04/22/2021	Notice to Shareholders - Receipt Disclosure of the Synthetic Voting Map	- -
04/16/2021	Notice to the Market - Perspective Lift
04/06/2021	Notice to the Market - Change of members in the Board	- -
03/23/2021	Material Fact - Clarification on Projections	- -
03/15/2021	Notice to the Market - New Chief Financial Officer	- -
03/03/2021	Notice to the Market - New Investor Relations Director	- -
01/12/2021	Notice to the Market - New Medical Officer	- -

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